Publications

Zieliński, P. S.; Zhang, Z.; Squillante, I.; Monreal Santiago, G.; Koch, M.; Portale, G.; Kamperman, M.; Krushynska, A.; Włodarczyk-Biegun, M. K. Designing Smartly: Understanding the Crystallinity of Melt Electrowritten Scaffolds. Engineering in Life Sciences 2025 25:e70020. https://doi.org/10.1002/elsc.70020 

Yan, L.; Zheng, W.; Muller, E.; Carl, P.; Hermans, T.; Monreal Santiago, G.* Timed formation and aging of complex coacervates using a volatile salt. Macromolecules 2025. 58, 3635−3642 https://doi.org/10.1021/acs.macromol.4c02728.

Preprint available in ChemRxiv: https://doi.org/10.26434/chemrxiv-2024-2k85w

Leon, L.*; Monreal Santiago, G.*; Spruijt, E.* Coacervation in Systems Chemistry. Commun. Chem. 2024 7:275
https://doi.org/10.1038/s42004-024-01358-1

Komáromy, D.; Monzón, D. M.; Marić, I.; Monreal Santiago, G.; Ottelé, J.; Altay, M.; Schaeffer, G.; Otto, S. Generalist versus Specialist Self-Replicators. Chem. Eur. J. 2024 e202303837

https://doi.org/10.1002/chem.202303837

Maric, I.; Yang, L.; Li, X.; Monreal Santiago, G.; Pappas, C.; Qiu, X.; Dijksman, J. A.; Mikhailov, K.; van Rijn, P.; Otto, S. Tailorable and Biocompatible Supramolecular-Based Hydrogels Featuring two Dynamic Covalent Chemistries. Angew. Chem. Int. Ed. 2023, e202216475 https://doi.org/10.1002/anie.202216475

Sun, J.; *Monreal Santiago, G.; Yan, F.; Zhou, W. Rudolf, P.; Portale, G.; *Kamperman, M. Bioinspired Processing of Keratin into Upcycled Fibers through pH- Induced Coacervation. ACS Sustainable Chem. Eng. 2023, 11, 1985−1994 https://doi.org/10.1021/acssuschemeng.2c06865

* = Corresponding author

Bartolec, B.;  Kiani, A.; Beatty, M. A.; Altay, M.; Monreal Santiago, G.;  Otto, S. Selection of diverse polymorphic structures from a small dynamic molecular network controlled by the environment. Chem. Sci. 2022, 13, 14300-14304. https://doi.org/10.1039/D2SC03909E

Sun, J; *Monreal Santiago, G.; Zhou, W.; Portale, G.; *Kamperman, M. Water-Processable, Stretchable, and Ion-Conducting Coacervate Fibers from Keratin Associations with Polyelectrolytes. ACS Sustainable Chem. Eng. 2022, 10, 48, 15968–15977. https://doi.org/10.1021/acssuschemeng.2c05411 

* = Corresponding author

+Matysiak, B. M.; +Monreal Santiago, G.; Otto, S. Teaching an Old Compound New Tricks: Reversible Transamidation in Maleamic Acids. Chem. Eur. J. 2022, 28 (40), e202201043. https://doi.org/10.1002/chem.202201043. 

+ = Equal contribution

Komáromy, D.; Tiemersma-Wegman, T.; Kemmink, J.; Portale, G.; Adamski, P. R.; Blokhuis, A.; Aalbers, F. S.; Marić, I.; Monreal Santiago, G.; Ottelé, J.; Sood, A.; Saggiomo, V.; Liu, B.; van der Meulen, P.; Otto, S. Stoichiometry Alone Can Steer Supramolecular Systems on Complex Free Energy Surfaces with High Selectivity. Chem 2021, 7 (7), 1933–1951. https://doi.org/10.1016/j.chempr.2021.05.020. 

Maity, S.; Ottelé, J.; Monreal Santiago, G.; Frederix, P. W. J. M.; Kroon, P.; Markovitch, O.; Stuart, M. C. A.; Marrink, S. J.; Otto, S.; Roos, W. H. Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization. J. Am. Chem. Soc. 2020, 142 (32), 13709–13717. https://doi.org/10.1021/jacs.0c02635. 

Monreal Santiago, G.; Liu, K.; Browne, W. R.; Otto, S. Emergence of Light-Driven Protometabolism on Recruitment of a Photocatalytic Cofactor by a Self-Replicator. Nat. Chem. 2020, 12 (7), 603–607. https://doi.org/10.1038/s41557-020-0494-4. 

ChemRxiv link

Behind the paper in Nature Chemistry Community

News and Views article in Nature Chemistry

Highlighted in different popular news outlets [1][2][3][4][5]

Cvrtila, I.; Fanlo-Virgós, H.; Monreal Santiago, G.; Otto, S.  Accelerating Hydrazone Exchange by UV Irradiation J. Sys. Chem. 2020, 8, 73-81. Link

Bartolec, B.; Leonetti, G.; Li, J.; Smit, W.; Altay, M.; Monreal Santiago, G.; Yan, Y.; Otto, S. Emergence of Compartments Formed from Unconventional Surfactants in Dynamic Combinatorial Libraries. Langmuir 2019, 35 (17), 5787–5792. https://doi.org/10.1021/acs.langmuir.8b03662.

Malakoutikhah, M.; Schaeffer, G.; Monreal Santiago, G.; Yang, S.; Marić, I.; Otto, S. Cross-Catalysis between Self-Replicators of Different Handedness. J. Sys. Chem. 2019, 7, 9-18. Link to Abstract. 

Cvrtila, I.; Fanlo-Virgós, H.; Schaeffer, G.; Monreal Santiago, G.; Otto, S. Redox Control over Acyl Hydrazone Photoswitches. J. Am. Chem. Soc. 2017, 139 (36), 12459–12465. https://doi.org/10.1021/jacs.7b03724. 

Hertzberg, R.; Monreal Santiago, G.; Moberg, C. Synthesis of the Β3-Adrenergic Receptor Agonist Solabegron and Analogous N-(2-Ethylamino)-β-Amino Alcohols from O-Acylated Cyanohydrins – Expanding the Scope of Minor Enantiomer Recycling. J. Org. Chem. 2015, 80 (5), 2937–2941. https://doi.org/10.1021/acs.joc.5b00322.